8.five 58.two 58.two 62.26 63.29 63 62 62 62.1 62.5 62.8 61.9 62.two 60.9 59.7 60.five 62 62 63.16 61.9 62.07 62.48 59.4 58.2 62 59.7 60 58.16 17 59 59 32.1 37.two 72 71 75 66.2 69.7 65.four 69.7 61.9 65 67 73 64 62 70 84 63.06 67.five 66.7 63.9 62.three 61.8 64.9 68.5.7 five.NoKneeNoNot mentionedKneeYesNoHipBensen et al. 1999 [52]Celecoxib 200 mg Naproxen 1000 mg Placebo9 10NoNoKneeBingham et

8.5 58.two 58.two 62.26 63.29 63 62 62 62.1 62.five 62.eight 61.9 62.2 60.9 59.7 60.five 62 62 63.16 61.9 62.07 62.48 59.four 58.two 62 59.7 60 58.16 17 59 59 32.1 37.2 72 71 75 66.2 69.7 65.four 69.7 61.9 65 67 73 64 62 70 84 63.06 67.five 66.7 63.9 62.3 61.eight 64.9 68.5.7 five.NoKneeNoNot mentionedKneeYesNoHipBensen et al. 1999 [52]Celecoxib 200 mg Naproxen 1000 mg Placebo9 10NoNoKneeBingham et al. 2007a [53]Etoricoxib 30 mg Celecoxib 200 mg PlaceboYesNoHip/kneeBingham et al. 2007b [53]Etoricoxib 30 mg Celecoxib 200 mg PlaceboYesNoHip/knee-12.29 (22.63)a -23.46 (24.51)aBoswell et al. 2008 [54] Burch et al. 2007 [55]f Study NCT00833794 Chappell et al. 2011 [26]b Study NCT00433290 Chappell et al. 2009 [27]b Study NCT00408421 Clegg et al. 2006 [56]b, eCelecoxib 200 mg Placebo Tramadol 200?00 mg Placebo Duloxetine 60?20 mg Placebo Duloxetine 60?20 mg Placebo Celecoxib 200 mg Placebo8.8NoNoKnee-18.46 (23.46)a 34.96 (14.74)g 35.20 (15.13)g -20.50 (11.87) -16.25 (12.26) -24.01 (16.07) -16.81 (13.67) -17.95 (14.98) -14.58 (15.99) -16.24 (24.22) -22.ten (24.16) -25.60 (24.58) -17.73 (24.28)YesNoKnee51.63 (ten.45) 53.82 (9.04) 57.ten (12.15) 56.51 (11.12) 47.10 (13.36) 46.23 (13.49) 61.13 (14.Buy156939-62-7 02) 60.37 (15.93) 58.21 (15.26) 59.95 (15.49)8.14 six.74 9.04 9.3 10.1 9.five 8.five 7.6 eight 7.NoYesKneeNoYesKneeNoYesKneeDeLemos et al. 2011 [57]Tramadol 200 mg Tramadol 300 mg Celecoxib 200 mg PlaceboNoNoHip/kneePage four ofMyers et al. BMC Musculoskeletal Issues 2014, 15:76 http://biomedcentral/1471-2474/15/Table 1 Qualities of all integrated research (Alphabetically ordered) (Continued)Essex et al. 2012 [58]c Celecoxib 200 mg Naproxen 1000 mg Fishman et al. 2007 [59] Tramadol 200 mg Tramadol 300 mg Placebo Fleischmann et al. 2006 [60]b296 293 107 105 224 444 231 63 66 201 201 205 242 124 244 122 205 205 207 207 218 420 424 224 221 56 56 51 224 21360 60.7 61 60 61 61.three 61.five 62.52 62.45 59.1 58.five 56.4 33.2 32.7 33 33 60.4 60.3 62 64 64 62.9 61.7 62.93 63.16 64.09 62 64 62.1 62.356.15 (15.42) 56.56 (15.73) 58.42 (13.99) 63.74 (15.21) 61.29 (14.16) 50.94 (16.76) 48.65 (16.97)-23.13 (19.71) -23.54 (19.61) -24.39 (21.19)a -25.54 (44.61) -18.82 (38.32) -16.67 (18.95) -9.69 (16.82) 41.60 (20.50)g 50.40 (22.50)g -21.25 (23.92) -20.27 (23.81) -14.19 (23.45) -5.56 (40.51)a, -4.36 (41.89)a,h64.9 67.6 59.8 65.7 61.six 67.1 66.two 65.1 59.1 63.7 59.two 68.eight 61.2 66.7.two eight.YesNoKneeNoYesKneeCelecoxib 200 mg Placebo6.2,4-Dichlorofuro[3,2-d]pyrimidine structure 7 6.PMID:24078122 six 7.94 7.76 7.7 eight 7.NoNoKneeFleischmann et al. 2001 [61]bTramadol 200?00 mg PlaceboYesNoKneeGana et al. 2006 [36]Tramadol 200 mg Tramadol 300 mg Placebo63.77 (13.14) 60.ten (14.73) 61.82 (14.82)NoNoHip/kneeHochberg et al. 2011a [62]Celcoxib 200 mg PlaceboYesYesKneeHochberg et al. 2011b [62]Celecoxib 200 mg Placeboh62.7 63.KneeKivitz et al. 2002 [63]Naproxen 1000 mg Placebo55.91 55.72 52.29 (16.73) 51.88 (17.24) 52.81 (15.60) 52.60 (14.93) 51.77 (15.09) 63.84 (13.89) 63.76 (13.36) 68.11 (ten.83) 64.70 (15.71)a 63.80 (15.00) 64.95 63.18 64.-18.79 (19.78) -14.04 (19.71) -10.10 (15.92) -11.98 (16.07) -4.38 (15.70) -15.31 (16.47) -11.77 (19.03) -22.19 (15.91) -21.91 (15.81) -13.26 (15.17) -14.93 (26.09) -0.87 (19.72) -24.90 (23.14) -21.73 (22.49) -14.43 (21.23)63 64 65 66 67 68.three 71.9 77.2 78.3 82.1 68 78 77.7 73.7 75.9.4 8.3 7.two 7.3 7.9 four.four three.9 five.88 6.25 six.NoNoKneeKivitz et al. 2001 [64]Celecoxib 200 mg Naproxen 1000 mg PlacebobYesNoHipLehmann et al. 2005 [65]Celecoxib 200 mg PlaceboYesyesKneeLeung et al. 2002 [66]Etoricoxib 60 mg Naproxen 1000 mg PlaceboYesNoHip/kneeMarkenson et al. 2005 [67]b, eOxycod.