Ller, SM, Connelly, JP, Maeder, ML, Joung, JK and Porteus, MH (2008). Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. Mol Ther 16: 707?17. 24. Maeder, ML, Thibodeau-Beganny, S, Osiak, A, Wright, DA, Anthony, RM, Eichtinger, M et al. (2008). Fast “open-source” engineering of customized zinc-finger nucleases for very efficient gene modification. Mol Cell 31: 294?01. 25. Maeder, ML, Thibodeau-Beganny, S, Sander, JD, Voytas, DF and Joung, JK (2009). Oligomerized pool engineering (OPEN): an `open-source’ protocol for producing customized zinc-finger arrays. Nat Protoc 4: 1471?501. 26. Hurt, JA, Thibodeau, SA, Hirsh, AS, Pabo, CO and Joung, JK (2003). Very particular zinc finger proteins obtained by directed domain shuffling and cell-based choice. Proc Natl Acad Sci USA one hundred: 12271?2276. 27. Sander, JD, Dahlborg, EJ, Goodwin, MJ, Cade, L, Zhang, F, Cifuentes, D et al.Price of Fmoc-Phe(4-F)-OH (2011).(S)-3-Phenylmorpholine manufacturer Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Solutions eight: 67?9. 28. Miller, JC, Holmes, MC, Wang, J, Guschin, DY, Lee, YL, Rupniewski, I et al. (2007). An enhanced zinc-finger nuclease architecture for extremely particular genome editing. Nat Biotechnol 25: 778?85. 29. Bibikova, M, Golic, M, Golic, KG and Carroll, D (2002). Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161: 1169?175. 30. Cornu, TI, Thibodeau-Beganny, S, Guhl, E, Alwin, S, Eichtinger, M, Joung, JK et al. (2008). DNA-binding specificity is really a big determinant of your activity and toxicity of zinc-finger nucleases. Mol Ther 16: 352?58.PMID:24238415 31. Beumer, K, Bhattacharyya, G, Bibikova, M, Trautman, JK and Carroll, D (2006). Efficient gene targeting in Drosophila with zinc-finger nucleases. Genetics 172: 2391?403. 32. Szczepek, M, Brondani, V, B hel, J, Serrano, L, Segal, DJ and Cathomen, T (2007). Structure-based redesign with the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25: 786?93. 33. Pruett-Miller, SM, Reading, DW, Porter, SN and Porteus, MH (2009). Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet five: e1000376. 34. Elliott, B, Richardson, C, Winderbaum, J, Nickoloff, JA and Jasin, M (1998). Gene conversion tracts from double-strand break repair in mammalian cells. Mol Cell Biol 18: 93?01. 35. Wah, DA, Bitinaite, J, Schildkraut, I and Aggarwal, AK (1998). Structure of FokI has implications for DNA cleavage. Proc Natl Acad Sci USA 95: 10564?0569.Molecular Therapy ucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under a Inventive Commons Attribution-NonCommercialNoDerivative Works three.0 License. To view a copy of this license, take a look at http://creativecommons.org/licenses/by-nc-nd/3.0/Supplementary Information and facts accompanies this paper on the Molecular Therapy ucleic Acids web page (http://nature/mtna)moleculartherapy.org/mtna
Speedy communicationOutbreak triggered by the SARS-CoV-2 Omicron variant in Norway, November to DecemberLin T. Brandal1,* , Emily MacDonald1,* , Lamprini Veneti?, Tine Ravlo?, Heidi Lange?, Umaer Naseer?, Siri Feruglio?, Karoline Bragstad?, Olav Hungnes?, Liz E. eskaug?, Frode Hagen?, Kristian E. Hanch-Hansen?, Andreas Lind?, Sara Viksmoen Watle?, Arne M. Taxt?, Mia Johansen?, Line Vold?, Preben Aavitsland?, Karin Nyg d?, Elisabeth H. Madslien?1. Norwegian Institute of Public Well being, Oslo, Norway 2. Municipality of Oslo, Norway 3. Department.
