Se of thermal analysis for the characterization of your physicochemical compatibility involving drugs and excipients during the improvement of solid dosage types. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) had been utilized to study the thermal stability from the drug and with the physical mixture (drug/excipients) in strong binary mixtures (1:1). DSC thermograms demonstrated reproducible melting occasion in the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Facts recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of those strategies for the characterization of your drug/excipients interactions.2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access write-up under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).* Corresponding authors at: Division of Pharmaceutical Technologies, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciencias da Saude, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.156311-83-0 Data Sheet Tel.: +351 239 488 400; fax: +351 239 488 503 (E.B. Souto). ^ Laboratory of Nanotechnology and Nanomedicine (LNMED), Institute of Technology and Research (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Farolandia, Aracaju, SE CEP 49.032-490, Brazil. Tel.: +55 (79) 3218 2190×2599; fax: +55 (19) 98223 2223 (P. Severino). ^ E-mail addresses: [email protected] (E.B. Souto), [email protected] (P. Severino). Peer critique under duty of King Saud University.Production and hosting by Elsevierhttp://dx.doi.org/10.1016/j.jsps.2016.05.001 1319-0164 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access write-up beneath the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).one hundred 1. Introduction The development of a brand new pharmaceutical dosage kind includes preliminary pre-formulation studies for which information regarding the physical, chemical and mechanical properties in the formulation constituents is essential.1007882-58-7 site Mixture of drug/ excipient can have an effect on the long-term stability with the solid dosage type, too because the drug bioavailability, therapeutic efficiency and safety profile (de Oliveira et al.PMID:25040798 , 2013b; Tita et al., 2011). Also, the interactions amongst drug and excipients can impact the excellent on the mixture, such as the polymorphic type and crystallization profile of the drug, but also the formulation properties including the solubility in the mixture, color, odor, and taste (Wu et al., 2011). Thermoanalytical techniques are useful for the analysis of drug/excipient interactions during the development of new formulations according to classical solid dosage types (e.g. powders, tablets, capsules). The physical properties, stability, compatibility and interactions in between drugs and drugs/excipients is often assessed by the study of the alterations occurring inside the onset and endset temperatures, melting point and enthalpy (Mazurek-Wadolkowska et al., 2012). The advantages of Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) rely on the rapid sample processing, modest amount of sample required, and quick detection of physical interactions (Chadha and Bhandari, 2014; Severino et al., 2011). The improvement of solid dosage types (e.g. capsules.